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Just as Napoleon was transformed by the mutations of his pituitary, so was the Saint with the Lamp. And in both instances the contrasting modifications, from one extreme of glandular function to the other, supply us with the clue to the secret hand of their inner being and becoming, which worked upon the twists and turns of circumstance about them as a sculptor upon clay.

To what extent that shadow spreads depends upon the strength of the other glands of internal secretion, their ability to compensate or to stay inhibited. Whether or not the pituitary will be able to enlarge in its bony cradle seems to be the most important factor determining these variations.

The size of this bony box, and its capacity to yield to the various pressures of a pituitary enlarging to meet the demands of the organism, will often spell happiness or misery, success or failure, genius or idiocy for the man or woman. Certain possibilities are conceivable.

Just as much as the bones and viscera, the teeth and the hair, they show grossly how they are being influenced by all the endocrine glands. So thyroid types generally have a skeleton sparsely covered with a muscular mantle. Pituitary types have large well-developed muscles. The pineal gland has some definite relation to muscle chemistry not yet probed.

Thus, there is the sub-pituitary or pituitary insufficient type, in whom the excessive swelling of the gland causes headache, and a dull, heavy, tired feeling, a definite depression. Drowsiness, sleepishness, indifference to surroundings, general sluggishness of thought, feeling and reaction, a phlegmatic frilosity, all go with it.

But the ordinary giant is one in whom there is degeneration of the pituitary after too much action of the anterior and too little of the posterior glands. A tumor or disease process in the gland is most often responsible.

'Too kind too kind! she murmured; and she was not ironical." In the days of pituitary and thyroid hyperfunction we may be sure she would have been caustically and penetratingly ironical. The case of Oscar Wilde, as one of the high tragedies of English Literature and Life, attracted the attention of the whole world in its heyday, and even today evokes controversy.

They have also a good deal of hair upon the abdomen. The hair on the extremities varies a good deal with the pituitary. People with hair upon hands, arms and legs, alone, are generally pituitary, or have a striking pituitary streak in their make-up. When the adrenals increase in size in childhood, a remarkable triad follows general hairiness, adiposity and sexual precocity.

Sex exhibition differs in man and woman because of the differently combined internal secretions that are their substrates. The male's attitude, aggressive pursuit, is instigated by the compound adrenal and gonad endocrines. The female's various emulsions of coyness and display are motivated by posterior pituitary and gonad hormones in alliance.

In view of what has been said of the ante-pituitary as the gland of intellectuality, studies of intellectually gifted people having shown well functioning large pituitaries, and of mental defectives in a certain number of cases a small limited pituitary, it is justifiable to regard the factor of inherent capacity as a function of the ante-pituitary.