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Roderigo's elder brother, Don Pedro Luis de Lanzol y Borja, was made Gonfalonier of the Church, Castellan of all pontifical fortresses and Governor of the Patrimony of St. Peter, with the title of Duke of Spoleto and, later, Prefect of Rome, to the displacement of an Orsini from that office.

The reconciliation was sealed by a marriage between the two families; the city prefect, Giovanni della Rovere, Giuliano's brother, betrothing his eighteen-year-old son Francesco Maria to Angela Borgia, September 2, 1500. Angela's father, Giuffrè, was a son of Giovanni, sister of Alexander VI, and of Guglielmo Lanzol.

Among other members of the house of Mila settled in Rome was Don Pedro, whose daughter, Adriana Mila, we shall later find in most intimate relations with the family of her uncle Rodrigo. Of the sisters of this same Rodrigo, Beatrice was married to Don Ximenez Perez de Arenos, Tecla to Don Vidal de Villanova, and Juana to Don Pedro Guillen Lanzol. All these remained in Spain.

And again, just as we know nothing of her family origin, neither have we any evidence of what her circumstances were when she caught the magnetic eye of Cardinal Roderigo de Lanzol y Borja or Borgia as by now his name, which had undergone italianization, was more generally spelled.

It was Cardinal Roderigo de Lanzol y Borja who, in his official capacity of Archdeacon of Holy Church, performed the ceremony of coronation and placed the triple crown on the head of Pope Sixtus. It is probable that this was his last official act as Arch-deacon, for in that same year 1471, at the age of forty, he was ordained priest and consecrated Bishop of Albano.

One of the sisters of Calixtus, Catarina Borgia, was married to Juan Mila, Baron of Mazalanes, and was the mother of the youthful Juan Luis. Isabella, the wife of Jofrè Lanzol, a wealthy nobleman of Xativa, was the mother of Pedro Luis and Rodrigo, and of several daughters. The uncle adopted these two nephews and gave them his family name, thus the Lanzols became Borgias.

The Cardinal Vice-Chancellor Roderigo de Lanzol y Borja led this accession, with the result that the Cardinal of Siena became Pontiff as Pius II and was naturally enough disposed to advance the interests of the man who had been instrumental in helping him to that eminence. Thus, his position at the Vatican, in the very face of all hostility, became stronger and more prominent than ever.

This needs not to be dilated upon here; suffice it that in February of 1456 he gave the scarlet hat of Cardinal-Deacon of San Niccolo, in Carcere Tulliano, to his nephew Don Roderigo de Lanzol y Borja. Like his uncle he had studied jurisprudence at the University of Bologna and mentally and physically he was extraordinarily endowed.

We have it on the word of Cardinal Ammanati the same gentleman who, with Roderigo de Lanzol y Borja made so scandalously merry in de Bichis' garden at Siena that Cardinal Riario's luxury "exceeded all that had been displayed by our forefathers or that can even be imagined by our descendants"; and Macchiavelli tells us that "although of very low origin and mean rearing, no sooner had he obtained the scarlet hat than he displayed a pride and ambition so vast that the Pontificate seemed too small for him, and he gave a feast in Rome which would have appeared extraordinary even for a king, the expense exceeding 20,000 florins."

Alfonso Borja was a Valencian, born at Jatiba; he was secretary to the King or Aragon; then Bishop of Valencia, later Cardinal, and lastly Pope, by the name of Calixtus III. While Calixtus lives, the Spaniards are all-powerful in Rome. Calixtus protects his nephews, sons of his sister Isabel and a Valencian named Lanzol or Lenzol.