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It was entrusted to Garcia Jofre de Loaysa, with del Cano as pilot-major, and other survivors of Magellan's armada. They sailed from Coruna in July, 1525, with an armament of seven ships. Every precaution was taken to ensure the success of the voyage, but the expedition proved a most disastrous one notwithstanding.

These fleets are to trade in the Moluccas, or in any other lands and islands discovered within Castile's demarcation. The House of Trade for the spice regions is to be established at Corunna. Madrid, April 5, 1525. Fray García Jofre de Loaisa, a commander of the order of St. John, is appointed captain-general of the fleet now fitting out at Corunna for the Moluccas, and governor of those islands.

One of the sisters of Calixtus, Catarina Borgia, was married to Juan Mila, Baron of Mazalanes, and was the mother of the youthful Juan Luis. Isabella, the wife of Jofrè Lanzol, a wealthy nobleman of Xativa, was the mother of Pedro Luis and Rodrigo, and of several daughters. The uncle adopted these two nephews and gave them his family name, thus the Lanzols became Borgias.

After his death the Spaniards completed the circle of his discoveries. At this time the name of Negros was fixed, which even now is called Islas de los Pintados. For years the Spaniards called the entire archipelago Islas de Poniente; gradually, after the expedition of Don Fray Garcia Jofre de Loaisa , the new title of the Philippines prevailed, through Salazar.