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There are people with hyper-pituitarism who exhibit the highest mental powers. In them is an increased activity of the posterior lobe in association with enlargement and hyperfunction of the anterior, overgrowth is not so marked, and the individual is lean and mentally acute.

We have here an absolutely typical pituitary history, with another case of pituitocentric natural ability. What happens when pituitary hyperfunction or superiority becomes underfunction or inferiority is precisely as Strachey has described so cleverly of the "ministering angel": the acrid, thin and keen degenerate every time into the amiable, fat and dull.

Concomitantly, there is a changed, a more matured and steadier outlook upon life, all due to stimulation of the anterior pituitary, controller of growth, physical and mental. In general, the major endocrines, the pituitary, the adrenals, and the thyroid should hypertrophy and hyperfunction during pregnancy.

'Too kind too kind! she murmured; and she was not ironical." In the days of pituitary and thyroid hyperfunction we may be sure she would have been caustically and penetratingly ironical. The case of Oscar Wilde, as one of the high tragedies of English Literature and Life, attracted the attention of the whole world in its heyday, and even today evokes controversy.