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Ichthyosis is a disease of the skin characterized by a morbid development of the papillae and thickening of the epidermic lamellae; according as the skin is affected over a larger or smaller area, or only the epithelial lining of the follicles, it is known as ichthyosis diffusa, or ichthyosis follicularis.

Thus a granulating surface may be covered entirely by the ingrowing of the cutaneous epithelium from the margins; or islets, originating in surviving cells of sebaceous glands or sweat glands, or of hair follicles, may spring up in the centre of the raw area. Such islets may also be due to the accidental transference of loose epithelial cells from the edges.

Water, or any other fluid thrown into this organ, has a tendency to disorder the mucous follicles, to dry up their secretions and thus prevent the efflux of some of Nature's necessities.

This is a cancer originating in the sweat glands or sebaceous follicles, or in the fœtal residues of cutaneous glands. The cells are small and closely packed together in alveoli or in reticulated columns; cell nests are rare. It is rare on the trunk or limbs. It commences as a small flattened nodule in the skin, the epidermis over it being stretched and shining.

The exact location of an abscess also may furnish a key to its source; in axillary abscess, for example, if the suppuration is in the lymph glands the infection has come through the afferent lymphatics; if in the cellular tissue, it has spread from the neck or chest wall; if in the hair follicles, it is a local infection through the skin.

About every twenty-eight days, one of the follicles swells, becomes filled with liquid, pushes or is pushed to the surface of the ovary, there to rupture and expel into the abdominal cavity the tiny ripe ovum. The rest of the torn follicle makes itself over into a peculiar yellowish body, the true corpus luteum, should pregnancy occur.

The difference between the hair of the lighter and darker races is a difference of degree, not of kind, and can be easily measured. If the hair follicles of a China-man, a European, and a Negro are cut across transversely, it will be found that the diameter of the first is 100 by 77 to 85, the second 100 by 62 to 72, while that of the Negro is 100 by 40 to 60.

In the strings the young ova are distinguished by their considerable size from the surrounding follicle-cells. Two young Graafian follicles, isolated. In the male mammals there is the same fusion of the Mullerian and Wolffian ducts at their lower ends.

Bullyings. Bumpings. Bleedings. Bucketings with cold water. Knockings down. Kneeling on his chest till they broke it in, etc. etc.; after the medieval or monkish method: but that would not do. Bumpsterhausen's blue follicles stuck there still. Then Coaxing. Kissing. Champagne and turtle. Red herrings and soda water. Good advice. Gardening. Croquet. Musical soirees. Aunt Salty. Mild tobacco.

During the entire child-bearing period, or from about the age of fifteen to forty-five years, the development of the Graafian follicles and the discharge of the ova are continually taking place. The liberation of the ova usually takes place at definite times, which in general coincide with the menstrual epochs, one or more ova being set free at each period; but this is by no means invariable.