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Another order of recent researches is that made into the toxines produced by fatigue; Weichardt succeeded in isolating these toxines, and in fabricating anti-toxines with which he experimented successfully on rats. The experiments were also repeated in a clinic.
Some of them are carried broadcast in the blood current, while others remain at the point of entrance; in either case they elaborate certain products, termed toxines, which act, either locally or through the circulation, to cause the disease.
These toxines eventually kill the micro-organisms that produced them, quite as an animal may be smothered in its own exhalations; or at least they would do so if the "host" survived long enough for the completion of the process. Meantime, they have either killed the "host" or been defeated by certain very interesting natural processes.
This poison is easily obtained by causing the diphtheria bacillus to grow in common media in the laboratory for a while, and the toxines develop in quantity; then, by proper filtration, the bacteria themselves can be removed, leaving a pure solution of the toxic poison. Small quantities of this poison are inoculated into the horse at successive intervals.
Moreover, it is not the actual microbes which cause disease, but their toxines. Thus the theories of toxines seemed to be the true guide for researches; but then we entered into a sea of complications, and it is obvious that only "aspects" and "attributes" of immunity are accessible to us, but that the substance, the last word, underlying all those aspects which research has revealed is: mystery.
With regard to the appearance of the toxines, it was found that they were abundantly produced during the performance of "wearisome" work, whereas there were only traces of them to be found when the work was "interesting."
From this point of view, I should say that the ponogenic co-efficients might find a more practical and rational application than that of the revelation of "programs"; indeed these co-efficients indicating the production of toxines would appear destined to determine the dose of anti-toxine necessary to nullify the evil effects resulting from each different subject of instruction.
The further combat is between the poisonous products, termed toxines, engendered by the bacteria and certain antidotal substances, called antitoxines, newly created in the watery portion of the blood by some wonderful provision of Nature that is not yet well understood.
The doctor's long words sounded dreadfully in her ears: general sepsis, blood poisoning, a system overwhelmed by the toxines of virulent microbes; they reverberated in her ears like so many sentences of death. Was there any hope that this outflowing life would ever turn in its course and return like an incoming tide?
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