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Men coming to Klondyke should be sober, strong and healthy. They should be practical men, able to adapt themselves quickly to their surroundings. Special care should be taken to see that their lungs are sound, that they are free from rheumatism and rheumatic tendency, and that their joints, especially knee joints, are strong and have never been weakened by injury, synovitis or other disease.

As a result of acute synovitis a chronic synovial distension of the tarsal sheath occurs. Bog spavin is often present in case of thoroughpin but the two conditions are separate and distinct excepting in that both may occur simultaneously and as the result of the same cause. Some animals are undoubtedly predisposed to disease of synovial structures.

Acute bursitis and thecitis is of frequent occurrence in horses because of direct injury from contusion, punctures and other forms of traumatism. These synovial membranes, with few exceptions, when inflamed occasion a synovitis that may be very acute, yet there is less manifestation of pain than in arthritis.

But a puncture made in a similar manner and with the same instrument without due regard to asepsis is likely to cause an infectious synovitis and arthritis usually follows.

In the Bones, lesions occur which assume the clinical features of an evanescent periostitis, the patient complaining of nocturnal pains over the frontal bone, sternum, tibiæ, and ulnæ, and localised tenderness on tapping over these bones. In the Joints, a serous synovitis or hydrops may occur, chiefly in the knee, on one or on both sides.

When these tendon sheaths are opened, there follows a reaction which is quite analogous to that which exists in arthritic synovitis, but instead of ankylosis, adhesions with thecal obliteration occur. Rarely there result cartilaginous and osseous formations. The constitutional disturbances which characterize this condition vary with the degree of distress occasioned.