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I have before me now a letter from Kossuth written in January, 1854, from 21 Alpha Road, Regent's Park, to E. Sieveking and Son, members of my family, who were keenly interested in Hungarian politics, and who transacted many business arrangements for Kossuth from time to time while he was in England. The letter is on behalf of a friend of his, a Mr. Ernest Poenisch, and is written in German:

Indeed, I am quite unable to imagine how the periodical, and more especially the intermittent form, of headache is to be explained by what Dr. Sieveking describes rather ambiguously as a "change in the constitution of the blood."

While I agree with Dr. Sieveking as regards the importance to be ascribed to the first two factors cerebral hyperæmia and anæmia, in the production of the group of symptoms known as "headache," I fail to perceive why especial prominence should be given to the third condition mentioned by Dr. Sieveking.

He was a vegetarian, a total abstainer, and enemy of tobacco, vaccination, and vivisection. Memoir by I.G. Sieveking, 1909. Theologian, s. of a London banker, and brother of the above, was ed. at Ealing and Trinity Coll., Oxf., where he was the intimate friend of Pusey and Hurrell Froude. Taking orders he was successively curate of St. Clement's 1824, and Vicar of St. Mary's, Oxford, 1828.

Sieveking says: "Nothing is of more importance in reference to the pathology and therapeutics of the head than clear and well-defined notions on the physiological subject of the circulation within the cranium; for, among the various sources of medical skepticism, no one is more puzzling or more destructive of logical practice than a contradiction between the doctrine of physiology and the daily practice of medicine."

"Renewing my request to you, I sign myself, "Respectfully yours, "L. Kossuth. "To E. Sieveking and Son." In June, 1855, Francis Newman writes to Dr. Martineau, in answer to a letter from him:

E.H. Sieveking published in 1854 a most interesting paper on "Chronic and Periodical Headache." The views therein expressed are remarkable for their succinct and thoroughly scientific elucidation of the two great physiological principles involved in the consideration of by far the greater majority of instances of cephalalgia.

What Dr. Sieveking said in 1854 holds equally good to-day; and, indeed, the position then taken has received substantial indorsement through the positive results of more recent experimental physiology. Conspicuous in this connection are the inductive researches of Durham, Fleming, and Hammond, touching the modifications in the cerebral circulation during sleep and wakefulness.

Sieveking, "that it results either from fullness or emptiness, or, to use more modern terms, from hyperæmia or anæmia, applies equally to headache; but, to embrace all the causes of this affection we must add a third element, which, though most commonly complicating one of the above circumstances, is not necessarily included in them, namely a change in the constitution of the blood."