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Lorenzo de' Medici had set out for Naples, and the truce between the parties was in force, when, quite unexpectedly, Lodovico Fregoso, being in correspondence with some persons of Serezana, entered the place by stealth, took possession of it with an armed force, and imprisoned the Florentine governor.

Having formed this alliance, the pope desired the Genoese to concede Serezana to the Florentines, insisting that they had no right to detain what Agostino had sold, nor was Agostino justified in making over to the Bank of San Giorgio what was not his own.

Agostino Fregoso conceded Serezana to the San Giorgio, which readily accepted it, undertook its defense, put a fleet to sea, and sent forces to Pietra Santa to prevent all attempts of the Florentines, whose camp was in the immediate vicinity.

The Florentines found it would be essentially necessary to gain possession of Pietra Santa, for without it the acquisition of Serezana lost much of its value, being situated between the latter place and Pisa; but they could not, consistently with the treaty, besiege it, unless the people of Pietra Santa, or its garrison, were to impede their acquisition of Serezana.

To enjoy his power in security and repose, and conquer or resist his enemies at a distance, in the direction of Bologna he fortified the castle of Firenzuola, situated in the midst of the Appennines; toward Sienna he commenced the restoration and fortification of the Poggio Imperiale; and he shut out the enemy in the direction of Genoa, by the acquisition of Pietra Santa and Serezana.

Nor were the affairs of Genoa or of Tuscany in repose, for the Florentines kept the Count Antonio da Marciano on the borders of Serezana; and while the war continued in Lombardy, annoyed the people of Serezana by inroads and light skirmishes.

Upon this, Agostino Fregoso, who had seized Serezana, being unable to defend it, gave the fortress to the Bank of St. Giorgio. As we shall have frequent occasion to speak of St. Giorgio and the Genoese, it will not be improper, since Genoa is one of the principal cities of Italy, to give some account of the regulations and usages prevailing there.

The Florentines after the war of Serezana, lived in great prosperity until 1492, when Lorenzo de' Medici died; for he having put a stop to the internal wars of Italy, and by his wisdom and authority established peace, turned his thoughts to the advancement of his own and the city's interests, and married Piero, his eldest son, to Alfonsina, daughter of the Cavaliere Orsino.

Niccolo therefore besieged and took Serezana, and having committed great ravages, by way of further alarming the Florentines he proceeded to Lucca, spreading a report that it was his intention to go to Naples to render assistance to the king of Aragon.

The whole winter was consumed in negotiations between the Florentines and Genoese, which, by the pope's intervention, were carried on at Rome; but not being concluded upon the return of spring, the Florentines would have attacked Serezana had they not been prevented by the illness of Lorenzo de' Medici, and the war between the pope and King Ferrando; for Lorenzo was afflicted not only by the gout, which seemed hereditary in his family, but also by violent pains in the stomach, and was compelled to go the baths for relief.