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On October 19th, at the Guildhall, began the Great Oyer of Poisoning, as Coke described it, with the trial of Richard Weston. Thus at the very outset the dishonesty of the proceedings is apparent. Weston was an accessory. Both on his own evidence and that of Sir Gervase Elwes, besides the apothecary's boy in Flushing, Sir Thomas Overbury had died following upon an injection prepared by Loubel.

Therefore Loubel was the principal, and only after Loubel's conviction could the field have been extended to include Weston and the others. But Loubel was tried neither then nor subsequently, a circumstance regarded by many as the most mysterious part of what is known as the Overbury mystery, whereas, in fact, it is the clue to it.

An English lad, one Reeves, an apothecary's assistant, thinking himself dying, had confessed at Flushing that Overbury had been poisoned by an injection of corrosive sublimate. Reeves himself had given the injection on the orders of his master, Loubel, the apothecary who had attended Overbury on the day before his death. Winwood sought out Loubel, and from him went to Sir Gervase Elwes.

Her confession, however, shackled Somerset at his trial. It put her at the King's mercy. Without endangering her life Somerset dared not come to the crux of his defence, which would have been to demand why Loubel had been allowed to go free, and why the King's physician, Mayerne, had not been examined.

It was never proved that it was Anne Turner and Lady Essex who corrupted the lad Reeves, who with Weston administered the poisoned clyster that murdered Overbury. Nothing was done at all to absolve the apothecary Loubel, Reeves's master, of having prepared the poisonous injection, nor Sir Theodore Mayerne, the King's physician, of having been party to its preparation.

He maintained that he had been told to recommend Weston by Lady Essex and the Earl of Northampton. The next person to be examined by Coke was the apothecary Loubel, he who had attended Overbury on the day before his death. Though in his confession the lad Reeves said that he had been given money and sent abroad by Loubel, this was a matter that Coke did not probe.

Loubel told Coke that he had given Overbury nothing but the physic prescribed by Sir Theodore Mayerne, the King's physician, and that in his opinion Overbury had died of consumption. With this evidence Coke was very strangely content or, at least, content as far as Loubel was concerned, for this witness was not summoned again.