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By Intra-muscular Injection. This consists in introducing the drug by means of a hypodermic syringe into the substance of the gluteal muscles. The syringe is made of glass, and has a solid glass piston; the needle of platino-iridium should be 5

To arrest the absorption of toxins intra-muscular injections of 10,000 units of serum are given daily into the muscles of the affected limb, or directly into the nerve trunks leading from the focus of infection, in the hope of "blocking" the nerves with antitoxin and so preventing the passage of toxins towards the spinal cord.

The application of volatile substances, such as ammonia or smelling-salts, to the nose; the administration by the mouth of sal-volatile, whisky or brandy, and the intra-muscular injection of ether, are the most speedily efficacious remedies.

In the course of a few hours, there is usually some indisposition, with a feeling of chilliness and slight rise of temperature; these symptoms pass off within twenty-four hours, and in a few days there is a decided improvement of health. Three or four days after an intra-muscular injection there may be pain and stiffness in the gluteal region.

Success has attended the use of a vaccine prepared from cultures of the organism; and the X-rays and radium, combined with the administration of iodides in large doses, or with intra-muscular injections of a 10

A similar deformity of the thumb is sometimes met with. Microscopical examination of the muscles shows that, prior to the deposition of lime salts and the formation of bone, there occurs a proliferation of the intra-muscular connective tissue and a gradual replacement and absorption of the muscle fibres.

The diagnosis of an intra-muscular tumour is made by observing that the swelling is situated beneath the deep fascia, that it becomes firm and fixed when the muscle contracts, and that, when the muscle is relaxed, it becomes softer, and can be moved in the transverse axis of the muscle, but not in its long axis.