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It has been shown experimentally in various ways that the necessary elements of the secretion can be furnished by feeding with the gland or its extracts, and that the cretinoid or myxedematous conditions could thus be cured or prevented.
In childhood, the subthyroid or thyroid deficient, the cretinoid type, the type resembling the cretin, is fairly common. The peasant's face, with the broad nose and the tough skin, coarse straight hair, the undergrowth, physical and mental, a persistent babyishness and a retardation of self-control development, make up the picture.
Generally flushed over the cheek-bones, there is undoubtedly a certain effeminate effect associated with it. At least, it is the least animal and brutish of the faces of man. On the other hand, the subthyroid face is that of the cretin and cretinoid idiot, in a mild degree.
A woman suffering with myxedema, the condition described by the English physician Gull as a cretinoid state supervening in the adult life of woman, has an insufficient amount of thyroxin in her blood and tissues. She is clumsy and awkward and will stumble when endeavoring to walk upstairs.
The disease was first described by Sir William Gull as a cretinoid change, and later by William Ord of London, who suggested the name. It is characterized clinically by a myxedematous condition of the subcutaneous tissues and mental failure, and anatomically by atrophy of the thyroid gland.
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