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Besides, the malignant condition has spread. There is pressure upon the submaxillary and subclavicular ganglia, and probably the axillary ganglia also. His respiration, circulation and digestion will soon be obstructed and strangulation will be rapid." He sighed and stood with an unlighted cigar in his mouth, his face rigid, his arms folded.

These are located, one on either side, just below and in front of the triangular bend in the lower jaw. The smallest of the salivary glands are the sublingual. They are situated in the floor of the mouth, on either side, at the front and base of the tongue. Ducts from the submaxillary and sublingual glands open into the mouth below the tip of the tongue.

The glands in nearest relation to the sore are those first affected, for example, the epitrochlear or axillary glands in chancre of the finger; the submaxillary glands in chancre of the lip or mouth; or the pre-auricular gland in chancre of the eyelid or forehead.

When the disease commences in the pre-auricular or submaxillary glands, it tends to spread to those along the carotid sheath: when the posterior auricular and occipital glands are first involved, the spread is to those along the posterior border of the sterno-mastoid.

Frequently added to this is redness of the buccal and nasal membranes. He refuses all solid food, and either will not drink or finds it difficult to swallow anything. His mouth is generally open, and contains a spumy matter exhaling an offensive smell. His tongue, charged with a great quantity of saliva, protrudes from his mouth, and the submaxillary glands are enlarged.