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But that these organs receive no pain from the defect or absence of these stimuli, as in darkness or silence. But that our other organs of perception, which have generally been called appetites, as of hunger, thirst, want of heat, want of fresh air, are liable to be affected with pain by the defect, as well as by the excess of their appropriated stimuli.

Finally he may come to lose himself with Kant or Hegel or Coleridge in philosophical theories about the nature of beauty, or to follow the curious analyses of experimental aesthetics in modern laboratories, where the psycho-physical reactions to aesthetic stimuli are cunningly registered and the effects of lines and colors and tones upon the human organism are set forth with mathematical precision.

A convincing proof that environment has been the creator of man is seen in the absolute adaptation of the nociceptors as manifested in their specific response to adequate stimuli, and in their presence in only those parts of the body which throughout the history of the race have been most exposed to harmful contacts.

And remember that the coats of the arteries are muscular and contractile under the influence of external stimuli, acting without the help of the consciousness, or when the consciousness is in abeyance.

The modification of the hones and of the wing, shoulders, and sternum by the functional stimuli involved in flying are obviously adaptations, and in my opinion are only to be explained as the hereditary effects of functional stimulation, like all skeleto-muscular adaptations.

Hence the drunkard ceases to attend to external stimuli, and as volition is now also suspended, the trains of his ideas become totally inconsistent as in dreams, or delirium: and at length a stupor succeeds from the great exhaustion of sensorial power, which probably does not even admit of dreams, and in which, as in apoplexy, no motions continue but those from internal stimuli, from sensation, and from association.

This method has been used by others. Physical methods consist of certain stimuli of sight, hearing, and touch. Taste and smell have generally given negative results. Fixation of the gaze has been the most successful, but the ticking of a watch has been used.

We should prefer to think of these differences, however, neither as a phase of biological differentiation as structural change nor as functional adaptation by differentiation of reactions to the same stimuli, but as the effect of the new consciousness of desires that came with the rise of man from the animal stage, and the conditions under which these desires could and must be realized.

For these powerful stimuli excite pain at the same time, that they produce irritation; and this pain not only excites fibrous motions by its stimulus, but it also produces volition; and thus all these stimuli acting at the same time, and sometimes with the addition of their associations, produce so great exertion as to expend the whole of the sensorial power in the affected fibres.

In fact, one never sees purposeful acts and laughter associated. According to its severity, an isolated stimulus causes either an action or laughter. The ticklish points in our bodies were probably developed as a means of defense against serious attacks and of escape from injurious contacts. Anger, fear, and grief are also strong excitants and, therefore, are stimuli to motor activity.