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In tertiary lesions there is greater difficulty in demonstrating the spirochæte, but small numbers have been found in the peripheral parts of gummata and in the thickened patches in syphilitic disease of the aorta. Noguchi and Moore have discovered the spirochæte in the brain in a number of cases of general paralysis of the insane.
Noguchi has made an emulsion of dead spirochætes which he calls luetin, and which gives a specific reaction resembling that of tuberculin in tuberculosis, a papule or a pustule forming at the site of the intra-dermal injection. It is said to be most efficacious in the tertiary and latent forms of syphilis, which are precisely those forms in which the diagnosis is surrounded with difficulties.
In scientific investigation the names of Takamine, Noguchi, Yatsu, Takami, Asakawa, and Iyenaga are well known. The names of those who have been more than ordinarily successful in business would make a long list. The most serious objections to the Japanese arise in the coast States where these immigrants have raised a serious labor problem.
This leads me to believe that, sooner or later, medical science will have to admit that the Wasserman and Noguchi tests reveal, in many instances at least, the effects of mercurial poisoning instead of the effects of syphilitic infection. And this would not be surprising since it is well known that mercury has very similar effects upon the system as syphilis.
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