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By the seventh day the apex of the papule is of a pale yellow color, and the black skin has the appearance of being dotted over with yellow wax. The papule then develops into nodules of cylindric shape, with a dome-shaped, thick, yellow crust. It is only with the crust off that there is any resemblance to a raspberry.
I have a specimen of steatetical whinstone or basaltes from some part of Cumberland, in which is contained many nodules of the most perfect and beautiful plumbago. It is dispersed through this stone in rounded masses of all sizes from a nut to a pin's head; and many of these are mixed with pyrites. There is therefore reason to believe that this plumbago had been in fusion.
It is met with most frequently in the tendo-calcaneus in gouty and rheumatic subjects who have overstrained the tendon, especially during cold and damp weather. There is localised pain which is aggravated by walking, and the tendon is sensitive and swollen from a little above its insertion to its junction with the muscle. Gouty nodules may form in its substance.
The sphaerulites and the little nodules of obsidian in these rocks so closely resemble, in general form and structure, concretions in sedimentary deposits, that one is at once tempted to attribute to them an analogous origin.
Near Cumana the formation of the calcareous breccia contains: first, a compact whitish grey limestone, the strata of which, sometimes horizontal, sometimes irregularly inclined, are from five to six inches thick; some beds are almost unmixed with petrifactions, but in the greatest part the cardites, the turbinites, the ostracites, and shells of small dimension, are found so closely connected, that the calcareous matter forms only a cement, by which the grains of quartz and the organized bodies are united: second, a calcareous sandstone, in which the grains of sand are much more frequent than the petrified shells; other strata form a sandstone entirely free from organic fragments, yielding but a small effervescence with acids, and enclosing not lamellae of mica, but nodules of compact brown iron-ore: third, beds of indurated clay containing selenite and lamellar gypsum.
It is by no means infrequent, however, that when recurrence takes place after an operation for the removal of cancer, the recurrent nodules make their appearance in the main scar or in the scars of stitches in its neighbourhood.
Fraenkel found these nodules in the myocardium in a case of chorea, showing the close relationship between it and rheumatism. While repeated careful examination of the heart during acute infections will generally show signs of endocarditis if it is present, even if there are no subjective symptoms, the disease may be so insidious as not to be noted until a valvular lesion occurs.
But when they are taken into the stomach of a mosquito belonging to the genus Anopheles or other closely related genera they are not digested but go on with their development, conjugation and fertilization taking place, resulting in a more elongated form which makes its way through the walls of the stomach on the outside of which are formed the little nodules discovered by Ross on his mosquitoes.
When a stick was thrust into the mass, it broke into many-sided lumps of the size of a tennis-ball, which separated, and fell apart in a heap, like assorted coals thrown from a scuttle, though white instead of black. These were the curious glacier nodules, "grains du glacier," or "Gletcherkörne," characteristic of glacier ice as contrasted with lake ice.
When the lymphatic network in the skin is diffusely infected, the appearance is either that of a multitude of secondary nodules or of a diffuse thickening, so that the skin comes to resemble coarse leather. On the wall of the chest this condition is known as cancer en cuirasse.
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