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Michelozzo of Florence was at Ragusa in 1463; George of Sebenico was at Ancona rather earlier; Onofrio de La Cava did work at Ragusa; before his time, George of Sebenico's friend, Giovanni Dalmatico, was working in Rome, in the third quarter of the fifteenth century.
And this circumstance it was, perhaps, that imposed upon Botallus, who thought he had discovered a new passage for the blood from the vena cava into the left ventricle of the heart; and I own that when I met with the same arrangement in one of the larger members of the mouse family, in the adult state, I was myself at first led to something of a like conclusion.
Others, however, have pointed out the discrepancy between the generally acknowledged purity of character of Florinda and the meaning of La Cava, and it is their opinion that Count Julian's daughter is merely legendary, and that La Cava refers in some allegorical way to the dissolute and voluptuous life which Rodrigo had been leading and which was in itself a good and sufficient reason for all the misfortunes which were to follow.
For after this I need say no more for to unfold the motion of the heart, but that when these concavities are not full of bloud, necessarily there runs some from the vena cava into the right, and from the veinous artery into the left; for that these two vessels are always full of it, and that their openings which are towards the heart cannot then be shut: But that assoon as there is thus but two drops of bloud entred, one in either of these concavities, these drops, which cannot but be very big, by reason that their openings whereby they enter are very large, and the vessels whence they come very full of bloud, are rarified and dilated because of the heat which they find therein.
Zacutus Lusitanus says that he once found a mass of flesh in place of the liver. Lieutaud is quoted as describing a postmortem examination of an adult who had died of hydropsy, in whom the liver and spleen were entirely missing. The portal vein discharged immediately into the vena cava; this case is probably unique, as no authentic parallel could be found.
In each organ separation and purification of the blood are effected and removal of the heterogeneous, not to mention how the heart sends its blood up to the brain after purification in the lungs, which is done by the arteries called carotids, and how the brain returns the blood, now vivified, to the vena cava just above where the thoracic duct brings in the chyle, and so back again to the heart.
The first contact and union of the vena cava with the pulmonary veins, which occurs before the cava opens properly into the right ventricle of the heart, or gives off the coronary vein, a little above its escape from the liver, is by a lateral anastomosis; this is an ample foramen, of an oval form, communicating between the cava and the pulmonary vein, so that the blood is free to flow in the greatest abundance by that foramen from the vena cava into the pulmonary vein, and left auricle, and from thence into the left ventricle.
The ride over the opposite side of the mountain was described as so uncommonly pleasant as made me long to ride it with assistance of a pony. That, however, was impossible. We arrived at a country house, near a large town situated in a ravine or hollow, which was called La Cava from some concavities which it exhibited.
Now from the liver arose one great vessel, the hepatic vein, from division of which the others were held to come off as branches. Of these branches, one, our common vena cava, entered the right side of the heart. For the blood that it conveyed to the heart there were two fates possible. These impurities and vapours gave its poisonous and suffocating character to the breath.
The effect of this arrangement plainly is to prevent all motion of the blood from the heart and vena cava, whether it be upwards towards the head, or downwards towards the feet, or to either side towards the arms, not a drop can pass; all motion of the blood, beginning; in the larger and tending towards the smaller veins, is opposed and resisted by them; whilst the motion that proceeds from the lesser to end in the larger branches is favoured, or, at all events, a free and open passage is left for it.
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