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With the single exception of George Caries, who seems to have had some Irish blood in his veins, these early missionaries were as English as Carey himself; and the greater number, as we can see from the names, were natives of Yorkshire. Moreover, William Carey knew of their work.

To complete her misery, caries of the right knee-cap supervened, a gnawing disease, the shooting pains of which caused her to cry aloud. Her poor body, to which dressings were continually being applied, became one great sore, which was irritated by the warmth of her bed, by her prolonged sojourn between sheets whose friction ended by breaking her skin.

In the septum of the nose, the nasal bones, and the hard palate, gummatous disease causes ulceration, which, beginning in the mucous membrane, spreads to the bones, and being complicated with septic infection leads to caries and necrosis. Syphilitic disease of the tibia may be taken as the type of the affection as it occurs in the long bones.

I could not walk without a stick, and each step I took made me cry out, so dreadfully did my foot hurt me." * The Bishop's residence. "So it was of some injury to the foot that the Blessed Virgin cured you?" Sophie did not have time to reply, for Sister Hyacinthe, who was listening, intervened: "Of caries of the bones of the left heel, which had been going on for three years," said she.

During all that month, distressed by Pierrette's horrible sufferings, Monsieur Martener made several journeys to Paris; there he consulted Desplein and Bianchon, and even went so far as to propose to them an operation of the nature of lithotrity, which consists in passing into the head a hollow instrument by the help of which an heroic remedy can be applied to the diseased bone, to arrest the progress of the caries.

The pressure of the articular surfaces against one another favours the progress of ulceration of cartilage and of articular caries. These processes are usually more advanced in the areas most exposed to pressure for example, in the hip-joint, on the superior aspect of the head of the femur, and on the posterior and upper segment of the acetabulum.

The case, said the doctor, had been one of caries of the bones of the left heel, with a commencement of necrosis necessitating excision; and yet the frightful, suppurating sore had been healed in a minute at the first immersion in the piscina. "Tell the gentlemen how it happened, Sophie," he added. The little girl made her usual pretty gesture as a sign to everybody to be attentive.

In periosteal tumours that do not ossify, there is merely erosion of bone, and the shadow is not unlike that given by caries; in ossifying tumours, the arrangement of the new bone on the surface is characteristic, and when it takes the form of spicules at right angles to the shaft, it is pathognomic.

In Antigua laboured Samuel Isles, Joseph Newby, and Samuel Watson; in Jamaica, George Caries and John Bowen; in St. Kitts and St. Croix, James Birkby; in Barbados, Benjamin Brookshaw; in Labrador, William Turner, James Rhodes, and Lister; and in Tobago, John Montgomery, the father of James Montgomery, the well-known Moravian hymn-writer and poet.

The occurrence of ulceration of cartilage and of articular caries is attended with the clinical signs of fixation of the joint from involuntary muscular contraction, wasting of muscles, and starting pains. These starting pains are the result of sudden involuntary movements of the joint.