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The subsequent degeneration and death of the granulation tissue under the necrotic influence of bacterial toxins results in disintegration and crumbling away of the trabecular framework of the portion of bone affected. Clinically, carious bone yields a soft grating sensation under the pressure of the probe. The macerated bone presents a rough, eroded surface.
Less frequently the trabecular framework is added to by the formation of new bone, resulting in a remarkable degree of sclerosis, and if, following upon this, there is caseation of the tubercle and death of the affected portion of bone, there results a sequestrum often of considerable size and characteristic shape, which, because of the sclerosis and surrounding endarteritis, is exceedingly slow in separating.
The trabecular framework of the bone undergoes erosion and absorption rarefying ostitis and either disappears altogether or only irregular fragments or sequestra of microscopic dimensions remain in the area affected.
The term caries is employed to indicate any diseased process associated with crumbling away of the trabecular framework of a bone. It may be considered as the equivalent of ulceration or molecular destruction in the soft parts. The carious process is preceded by the formation of granulation tissue in the marrow or periosteum, which eats away and replaces the bone in contact with it.
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