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Boils may be differentiated from syphilitic lesions of the skin by their acute onset and progress, and by the absence of other evidence of syphilis; and from the malignant or anthrax pustule by the absence of the central black eschar and of the circumstances which attend upon anthrax infection. Treatment.
The principal variation perceptible to me in the action of the vaccine virus generated in London from that produced in the country was its proving more certainly infectious and giving a less disposition in the arm to inflame. There appears also a greater elevation of the pustule above the surrounding skin.
In no case did I observe the smallest pustule, or even discolouration of the skin, like an incipient pustule, except about the part where the virus has been applied. "After all these symptoms had subsided and the arms were well, I inoculated four of this number with variolous matter, taken from a patient in another regiment.
By far the greater number on whom trials were made resisted it entirely; yet I found some on whose arm the pustule from inoculation was formed completely, but without producing the common efflorescent blush around it, or any constitutional illness, while others have had the disease in the most perfect manner. A case of the latter kind having been presented to me by Mr.
One woman he inoculated about a week previous to her accouchement, that her infant might be the more fully and conveniently exposed to the pustule; but, as in the former instances, no infection was given, although the child frequently slept on the arm of its mother with its nostrils and mouth exposed to the pustule in the fullest state of maturity.
Mary Hearn, twelve years of age, was inoculated with matter taken from the arm of Susan Phipps. 6th day: A pustule beginning to appear, slight pain in the axilla. 7th: A distinct vesicle formed. 8th: The vesicle increasing; edges very red; no deviation in its appearance at this time from the inoculated smallpox. 9th: No indisposition; pustule advancing.
The progress of the pustule, formed by the infection of the virus, was similar to that noticed in Case XVII, with this exception, its being free from the livid tint observed in that instance. CASE XX.-From William Summers the disease was transferred to William Pead, a boy of eight years old, who was inoculated March 28th.
A thread imbrued in some of this matter was sent to me, and with it two children were inoculated, whose cases I shall transcribe from my notes. Stephen Jenner, three years and a half old. 3d day: The arm shewed a proper and decisive inflammation. 6th: A vesicle arising. 7th: The pustule of a cherry colour. 8th: Increasing in elevation.
It is, doubtless, on this principle that the inoculated cow-pock pustule and its concomitant efflorescence may, in very irritable constitutions, produce this affection. The eruption I allude to has commonly appeared some time in the third week after inoculation. But this appearance is too trivial to excite the least regard.
Another important consideration appears to be the impossibility of the disease being communicated except by the actual contact of the matter of the pustule, and consequently the perfect safety of the remaining part of the family, supposing only one or two should wish to be inoculated at the same time.
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