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The injection of adrenalin causes striking brain-cell changes: first, a hyperchromatism, then a chromatolysis.
Histologic examinations of the brains of both dogs showed marked hyperchromatism in the brain receiving adrenalin, while the brain receiving no adrenalin showed no change. Here is a clear-cut observation on the action of adrenalin on the brain, for both the functional and the histologic tests showed that adrenalin causes increased brain action.
An animal, both of whose adrenals had been excised, showed no hyperchromatism in the brain-cells after the injection of strychnin, toxins, foreign proteins, etc.
The significance of this affinity of the brain for adrenalin begins to be seen when I call attention to the following striking facts: 1. Adrenalin alone causes hyperchromatism followed by chromatolysis, and in overdosage causes the destruction of some brain-cells.
It is, therefore, the purpose of this paper to present the definite results of laboratory researches which show certain relations between alterations in brain functions and physical changes in the brain-cells. Fear. Hyperchromatism was shown only in the presence of the activating stimuli or within a very short time after they had been received.
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