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The myeloma is also to be diagnosed from chondroma, from sarcoma, and from osteomyelitis fibrosa cystica. [Illustration: FIG.
The lesions in the bones resulting from actinomycosis and from mycetoma, have been described with these diseases. These include rickets, scurvy-rickets, osteomalacia, ostitis deformans, osteomyelitis fibrosa, fragilitas ossium, and diseases of the nervous system. Rickets or rachitis is a constitutional disease associated with disturbance of nutrition, and attended with changes in the skeleton.
Upon these findings Henderson based his opinion that the physiological properties of the tunica fibrosa and the skull are identical, realizing at the same time, that the rigidity of the corneo-sclera, because of its fibrous nature, is not as firm as the cranium. In accepting this belief the inference was that the cubic capacity of both coverings is fixed.
We have met with a fibroma in the interior of the lower end of the femur of an adult, causing expansion of the bone with decided increase in girth and liability to pathological fracture; it is possible that this represents the cured stage of osteomyelitis fibrosa. Myxoma, lipoma, and angioma of bone are all rare.
#Osteomyelitis Fibrosa.# This comparatively rare disease, which was first described by Recklinghausen, presents many interesting features.
The X-ray appearances of the bones affected are of a striking character; apart from the outgrowths of bone or "tumours" there is evident a widespread alteration in the internal architecture of the bones, which suggests analogies with other disturbances of ossification such as achondroplasia and osteomyelitis fibrosa.
The young connective tissue which replaces the marrow is not unlike that seen in osteomalacia; it is highly vascular and may show hæmorrhages of various date; there are abundant giant cells of the myeloma type, and degeneration and liquefaction of tissue may result in the formation of cysts, which, when they constitute a prominent feature, are responsible for the name osteomyelitis fibrosa cystica sometimes applied to the condition.
#Cysts of Bone.# With the exception of hydatid cysts, cysts in the interior of bone are the result of the liquefaction of solid tissue; this may be that of chondroma, myeloma, or sarcoma, but more commonly of the marrow in osteomyelitis fibrosa. Definition of terms Ankylosis.
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