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Every step of this evolution shows an increasing toxic state of the fluids in the bowels. After constipation is established the efforts at securing evacuations are of such a nature as to irritate the cecum. Drugs to force movement cause painful distentions of this portion of the bowels.
This is thought to be a defect in development. The changes that occur in the tissues of the eye appear to be largely due to the stretching consequent on the more or less uniform distentions of the globe as a result of hypertension. Cornea. Fissures occur in Descemet's membrane. Anterior Chamber. This is very deep in the greater number of cases. However, this rule has many exceptions.
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