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The development of the leg out of the fin is one of the most difficult and least understood problems of vertebrate comparative anatomy. The legs are at first weak and scarcely capable of supporting the body. Only gradually do they strengthen into the fore- and hind-legs of mammals, or into the legs and wings of birds and old flying reptiles. Changes in the circulatory and respiratory systems.

Whether digitalis shall be given at all, or how large the dose shall be depends on whether or not the patient has been taking digitalis in large quantities. He may already be overpowered with digitalis. In that case it would be contraindicated. Stroplianthin, especially when given intravenously, has been found to be a quickly acting circulatory stimulant.

Nature needs this automatic function; otherwise the vital needs of individual and race might be suppressed by other interests, and neglected. In the case of the sexual instinct, the mutual relations between the various parts of this circulatory process are especially complicated.

In fact, the body is a machine of the nature of an army, not of that of a watch or of a hydraulic apparatus. Of this army each cell is a soldier, an organ a brigade, the central nervous system headquarters and field telegraph, the alimentary and circulatory system the commissariat.

This well-known and clearly demonstrated fact ought to have suggested a problem to the minds of students: How do the protozoa of malaria enter the circulatory current of the blood?

It may be that this mother had access to illustrations of the babe in the womb which were shown and explained to the child, a boy. He was pleased and satisfied with the explanations. It meant nothing out of the ordinary any more than a primary lesson on the circulatory system did, it was knowledge on nature in its purity and simplicity taught by mother, and hence caused no surprise.

Soon after entering the circulatory system of the human host the parasites make their way into the lymphatics where they attain sexual maturity, and in due time new generations of the larval filariæ or microfilariæ are poured into the lymph, and finally into the definite blood-vessels, ready to be sucked up by the next mosquito that feeds on the patient.

The idea behind this supposition has been that, as the day draws to an end, the circulatory mechanism becomes fatigued, the vasomotor center exhausted, the tone of the blood vessels deficient, and the energy of the heart diminished, and the circulation to the cerebral arteries lessened. The ordinary pressure of the blood in the arteries of young and healthy men averages 110-120 mm. of mercury.

Its importance was not realized the circulatory and nervous systems receiving the lion's share of attention. In the second place, in holding post-mortems the organ was avoided, cut off, if in the way, and thrown into the slop bucket.

ABSCESS. This is an accumulation of pus in the tissues. It may be due to a severe bruise or contusion that is followed by the infection of the part with some of the pus-producing bacteria. Abscesses occur in certain infectious diseases. In strangles, the disease-producing organism may be carried to different regions of the body by the circulatory vessels.