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Crepitation or a grinding, rubbing sound due to the movement of the ends of the broken bones on one another occurs when the part is moved or manipulated with the hands. Pain, swelling and injury to the skin are other local symptoms. The new tissue or bone callus is formed by the bone-forming cells in the deeper layer of the periosteum and bone-marrow. The prognosis is unfavorable.
It most frequently originates from fascia, intermuscular connective tissue, periosteum, bone-marrow, and skin, and forms a rounded or nodulated tumour which appears to be encapsulated, but the capsule merely consists of the condensed surrounding tissues, and usually contains sarcomatous elements.
They are present, of course, in large numbers in the secretions from open sores and under the skin in closed sores. The nervous system, the walls of the blood-vessels, the internal organs, such as the liver and spleen, the bones and the bone-marrow, contain them.
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