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Le Gendre believes that the menopause exerts a deleterious effect on the kidneys, whether this be a congestion, followed by a diminution in the quantity of urine, or a sort of auto-intoxication due to the retention of a poison in the system that has been prevented from leaving by the ordinary path.

Of course, it was changes in the humors of the body that constituted the main causes for disease in her opinion, but it is well to remind ourselves that our frequent discussion of auto-intoxication in recent years is a distinct return to this. Some of Hildegarde's anticipations of modern ideas are, indeed, surprising enough.

"You weren't ten minutes getting here and you look as spick and span as if you had stepped out of a bandbox." "Look outside and you'll see that Gay and I have had a true case of auto-intoxication!" Outside the window there proved to be a smart, selfish roadster, battleship-gray with vivid scarlet trimmings. "Well!" Beatrice said in astonishment. At this identical moment she began to envy Trudy.

When these two factors coexist in their varying combinations, pathological increase of pressure results in short, glaucoma. Syphilis, rheumatism, gout, auto-intoxication and many other constitutional disorders are well recognized agencies which induce sclerosis in body tissues, so there can be little doubt that these conditions produce pathological sclerosis of the meshwork of the iris angle.

Of course, no reflections are called for here on the current American campaign of "Preparedness." Except for the degree of hysteria it appears to differ in no substantial respect from the analogous course of auto-intoxication among the nationalities of Europe, which came to a head in the current European situation.

We may in part account for Romanticism by recalling that it was the product of an age which was no longer in sympathy with its own tasks, an age of political miseries and restrained powers, which turned away from its own surroundings and sought to be free from all contact with them, striving to benumb its sensations by an auto-intoxication of dreams.

In this hypothesis we find a reason why cardiovascular disease may be caused by chronic infection, by auto-intoxication, by overwork, or by emotional excitation. We now see that the reason why we find so much difficulty in differentiating the numerous acute infections from each other is because they play upon the same kinetic chain.

The examination was painstaking and exhaustive; the diagnosis seemed ominous to the morbid patient; the whole process was a revelation to him of organs and functions and laws of eating and drinking unheard in his years of study. "Chronic intestinal indigestion with food decomposition and auto-intoxication, augmented by nicotine," the doctor said.

The presence of a colloid goiter is a suitable soil for the development of Graves' disease, and I fully recognize also the evidence that infection or auto-intoxication may be contributing factors and must be assigned their role.

When he reduces his diet the cells and fluids of his body free themselves of these by-products and he realizes a capacity quite unguessed in the past. "The same assumption explains the fact mentioned by Mr. Fletcher, that the hours of sleep can be reduced decidedly when the diet is cut down. It would seem as though a part of our sleep might often be due to avoidable auto-intoxication.