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Under his direction, in 1522, the search was attempted by Pascual de Andagoya, but he failed to get down the coast beyond the limit of Balboa’s exploration. Meanwhile clearer and more abundant reports of the rich and marvelous nation to be found somewhere below that point were circulated among the Spaniards, and their eagerness to reach it became intense.

Pascual de Andagoya tells the story of the rich land, "populous and fertile, yielding supplies of maize, and many fowls of the country, and certain small dogs which they also eat, and many deer and fish. This is a land of abundance of good fruits and of honey and wax, wherewith all the neighbouring countries are supplied. The bees are numerous, some of them yellow, and these do not sting."

Such was Pizarro's situation when, in 1522, Andagoya returned from his unfinished enterprise to the south of Panama, bringing back with him more copious accounts than any hitherto received of the opulence and grandeur of the countries that lay beyond.7 It was at this time, too, that the splendid achievements of Cortes made their impression on the public mind, and gave a new impulse to the spirit of adventure.

The president now mustered his army, of which Pedro Alfonzo de Hinojosa was lieutenant-general, and the licenciate Bendicto de Carvajal carried the royal standard, Don Pedro de Cabrera, Gomez de Alvarado, Juan de Saavedra, Diego de Mora, Francisco Hernandez, Rodrigo de Salazar, and Alfonzo de Mendoza were captains of cavalry; Don Balthazar de Castillo, Pablo de Menezes, Hernando Mexia de Guzman, Juan Alfonzo Palomino, Gomez de Solis, Francisco Mosquera, Don Ferdinand de Cardinas, the adelantado Andagoya, Francisco d'Olmos, Gomez d'Arias, and three other captains, Porcel, Pardaval, and Serna, commanded the infantry.

After this he was associated with Vasco Nunez de Balboa in establishing a settlement at Darien, and from Balboa he may first have heard rumours of Peru itself, for it was to Balboa that an Indian chief had said concerning some gold which had been collected from the natives: 'If this is what you prize so much that you are willing to leave your homes and risk even life itself for it, I can tell you of a land where they eat and drink out of golden vessels, and gold is as common as iron with you. Later, Pizarro was sent to traffic with the natives on the Pacific side of the isthmus for gold and pearls, and presently from the south came Andagoya, bringing accounts of the wealth and grandeur of the countries which lay beyond, and also of the hardships and difficulties endured by the few navigators who had sailed in that direction.

It was not till 1522 that a regular expedition was despatched in the direction south of Panama, under the conduct of Pascual de Andagoya, a cavalier of much distinction in the colony. But that officer penetrated only to the Puerto de Pinas, the limit of Balboa's discoveries, when the bad state of his health compelled him to reembark and abandon his enterprise at its commencement.6

The associates found no difficulty in obtaining the consent of the governor to their undertaking. After the return of Andagoya, he had projected another expedition, but the officer to whom it was to be intrusted died. Why he did not prosecute his original purpose, and commit the affair to an experienced captain like Pizarro, does not appear.

Almagro was to follow after with reënforcements and supplies in the second ship. One Andagoya had made a short excursion southward some time before, but they soon passed his latitude and were the first white men to cleave those southern seas.