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Endocrine inferiority is indeed the most frequent organic inferiority. And we may explain a number of mental types upon that basis. Thus the inferior gonado-centric, who has something wrong with his reproductive organs, will evolve in one of two directions. If his adrenal and thyroid are of poor quality, he will become the secluded introvert, shut off from the interests of normal life.

Little more than a hundred years ago, it was observed that certain organs, like the thyroid body in the neck, and the adrenal capsules in the abdomen, hitherto neglected because their function was hopelessly obscure, had a glandular structure. As in so much scientific advance, the discovery or improvement of a new instrument or method, a fresh tool of research, was responsible.

Throughout the great American continent the men may be said to be beardless: but in almost all tribes a few short hairs are apt to appear on the face, especially in old age...." Hair being an adrenal cortex trait, it is to be inferred that hairless families and races are more eunuchoid, and possess less of the adrenal cortex secretion than the more hairy.

Such a type, for instance, may be picked out by a football coach for an important position in a line-up, simply on the tremendous impressiveness of the muscle make-up, only to see him bowled over and out in the first scrimmage. The tone of muscles, the quality of resisting firmness or yielding softness, is essentially determined by the adrenal glands, especially in time of stress and strain.

Brain fag is closely associated with, if not dependent upon, adrenal fag, particularly of the cortex. Brain tissue and adrenal cortex tissue are near relatives, and a normal human brain never develops without a normal adrenal cortex. The adrenal type with an hypertrophied adrenal cortex is always efficient. Among women, the adrenal type is always masculinoid.

Long sharply pointed canines mean well-functioning adrenal gland equipment to start in with, inherited from a bellicose progenitor. No individual peculiarities of the teeth are accidental.

The increased action of the muscles of the heart and the blood-vessels increases the efficiency of the circulation; the secretion of the adrenal gland causes a rise in the blood-pressure; the increased action of the thyroid gland causes an increased metabolic activity; there is evidence that glycogen is actively called out, this being the most immediately available substance for the production of energy; the increased activity of the respiration is needed to supply the greater need of oxygen and the elimination of the increased amount of waste products; the dilatation of the nostrils affords a freer intake of air; the increased activity of the sweat-glands is needed to regulate the temperature of the body which the increased metabolism causes to rise.

Thyroid and adrenal balance determines the resistance to decay of the molars. Early decay of the molars in children is significant of insufficiency of the thyroid. When the first permanent molar, which should appear in the upper arch in its usual position between the sixth or eighth years, does not, there has been a prenatal disturbance of the pituitary, according to Chayes and others.

Besides its action upon the sex cells and the brain cells, the internal secretion of the adrenal cortex acts upon the pigment cells of the skin, blunting their sensitiveness to light. In degeneration of the interior of the gland, which destroys the medulla, but not the cortex, the color of the skin is left unmodified.

The distinction between men of theoretical genius, whose minds which could embrace a universe, and yet fail to manage successfully their own personal everyday lives, and the men of practical genius, who can achieve and execute, the great engineers, and industrial men lies in the balance between the ante-pituitary and the adrenal cortex primarily.